Publications | Jouline Lab

The PAS domain of the polarly localized histidine kinase FlrB in Vibrio cholerae controls class III flagellar transcription and contributes to intestinal colonization

Tue, 14 Oct 2025 12:54:38 +0000

Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate

Tue, 14 Oct 2025 12:32:12 +0000

Specificities of chemosensory receptors in the human gut microbiota

Tue, 14 Oct 2025 12:25:01 +0000

FliO is an evolutionarily conserved yet diversified core component of the bacterial flagellar type III secretion system

Tue, 14 Oct 2025 12:16:37 +0000

Structural and functional diversity of sensor domains in bacterial transmembrane receptors

Tue, 14 Oct 2025 12:07:00 +0000

Bacterial sensor evolved by decreasing complexity

Wed, 29 Jan 2025 20:51:35 +0000

The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction

Fri, 13 Dec 2024 20:37:45 +0000

START domains generate paralog-specific regulons from a single network architecture

Thu, 14 Nov 2024 20:34:58 +0000

FlhE functions as a chaperone to prevent formation of periplasmic flagella in Gram-negative bacteria

Sun, 14 Jul 2024 19:29:11 +0000

Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria

Fri, 12 Jul 2024 18:23:51 +0000

Framework for exploring the sensory repertoire of the human gut microbiota

Fri, 17 May 2024 18:19:56 +0000

MiST 4.0: a new release of the microbial signal transduction database, now with a metagenomic component

Fri, 05 Jan 2024 19:04:03 +0000

Attractant and repellent induce opposing changes in the four-helix bundle ligand-binding domain of a bacterial chemoreceptor

Mon, 11 Dec 2023 19:15:51 +0000

Diverse domain architectures of CheA histidine kinase, a central component of bacterial and archaeal chemosensory systems

Fri, 01 Dec 2023 19:12:30 +0000

The structural analysis of the periplasmic domain of Sinorhizobium meliloti chemoreceptor McpZ reveals a novel fold and suggests a complex mechanism of transmembrane signaling

Mon, 23 Oct 2023 17:46:38 +0000

Two disulfide-reducing pathways are required for the maturation of plastid c-type cytochromes in Chlamydomonas reinhardtii

Thu, 19 Oct 2023 17:56:30 +0000

Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor

Wed, 11 Oct 2023 18:09:02 +0000

Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor

Wed, 30 Aug 2023 18:00:33 +0000

Evolutionary history of MEK1 illuminates the nature of deleterious mutations

Mon, 14 Aug 2023 17:50:50 +0000

Three unrelated chemoreceptors provide Pectobacterium atrosepticum with a broad-spectrum amino acid sensing capability

Fri, 14 Jul 2023 17:23:55 +0000

Transmembrane Transcription Regulators Are Widespread in Bacteria and Archaea

Thu, 15 Jun 2023 17:42:03 +0000

Emergence of an Auxin Sensing Domain in Plant-Associated Bacteria

Tue, 28 Feb 2023 18:12:14 +0000

The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity

Fri, 03 Feb 2023 15:26:37 +0000

Is it possible to predict signal molecules that are recognized by bacterial receptors?

Mon, 23 Jan 2023 18:01:41 +0000

Diverse sensory repertoire of paralogous chemoreceptors Tlp2, Tlp3, and Tlp4 in Campylobacter jejuni

Mon, 14 Nov 2022 17:56:28 +0000

Photoactive Yellow Protein Represents a Distinct, Evolutionarily Novel Family of PAS Domains

Wed, 09 Nov 2022 16:57:38 +0000

Phyletic Distribution and Diversification of the Phage Shock Protein Stress Response System in Bacteria and Archaea

Mon, 23 May 2022 17:22:30 +0000

Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy

Wed, 16 Mar 2022 21:34:00 +0000

Amino acid sensor conserved from bacteria to humans

Tue, 01 Mar 2022 18:18:44 +0000

A species-specific functional module controls formation of pollen apertures

Tue, 29 Jun 2021 01:57:54 +0000

Diversity of bacterial chemosensory systems

Sat, 06 Mar 2021 02:21:38 +0000

The Campylobacter jejuni chemoreceptor Tlp10 has a bimodal ligand-binding domain and specificity for multiple classes of chemoeffectors

Wed, 06 Jan 2021 03:32:12 +0000

Origins and Molecular Evolution of the NusG Paralog RfaH

Wed, 28 Oct 2020 02:53:46 +0000

Identification and characterization of a novel CLCN7 variant associated with osteopetrosis

Fri, 23 Oct 2020 02:57:38 +0000

TREND: a platform for exploring protein function in prokaryotes based on phylogenetic, domain architecture and gene neighborhood analyses

Tue, 14 Apr 2020 03:01:04 +0000

How bacterial chemoreceptors evolve novel ligand specificities

Wed, 22 Jan 2020 04:04:58 +0000

MiST 3.0: an updated microbial signal transduction database with an emphasis on chemosensory systems

Sat, 23 Nov 2019 04:12:58 +0000

Trimeric structure of the ligand-binding domain suggests a mode of communication in bacterial chemoreceptors

Sun, 09 Jun 2019 03:32:48 +0000

A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species

Thu, 06 Jun 2019 03:29:54 +0000

Cross talk between chemosensory pathways that modulate chemotaxis and biofilm formation

Wed, 27 Feb 2019 04:34:36 +0000

IMPORTANCE In many bacteria, two or more homologous chemosensory pathways control several cellular functions, such as motility and gene regulation, in response to changes in the cell’s microenvironment. Cross talk between signal transduction systems is poorly understood; while generally it is considered to be undesired, in some instances it might be beneficial for coregulation of complex behaviors. We demonstrate that several receptors from the pathway controlling motility can physically interact with downstream components of the pathway controlling biofilm formation. We further show that a kinase from the pathway controlling motility can also phosphorylate a response regulator from the pathway controlling biofilm formation. We propose that cross talk between two chemosensory pathways might be involved in coordination of two types of cell behavior—chemotaxis and biofilm formation.

Characterization of squamous cell lung cancers from Appalachian Kentucky

Sat, 16 Feb 2019 04:37:20 +0000

Comparative study of the effect of disease causing and benign mutations in position Q92 on cholesterol binding by the NPC1 N-terminal domain

Thu, 06 Sep 2018 03:40:24 +0000

Conservation of the separase regulatory domain

Sat, 28 Apr 2018 03:43:09 +0000

Insights into the evolution of host association through the isolation and characterization of a human periodontal pathogen, Desulfobulbus oralis

Wed, 14 Mar 2018 03:51:31 +0000

Phylogenetic and protein sequence analysis of bacterial chemoreceptors

Mon, 12 Feb 2018 04:45:21 +0000

A novel PRRT2 pathogenic variant in a family with Paroxysmal Kinesigenic Dyskinesia and Benign Familial Infantile Seizures

Fri, 09 Feb 2018 04:47:16 +0000

Assigning chemoreceptors to chemosensory pathways in Pseudomonas aeruginosa

Tue, 28 Nov 2017 18:48:36 +0000

Sensory repertoire of bacterial chemoreceptors

Wed, 25 Oct 2017 17:51:08 +0000

Two-Component Signal Transduction: a Special Issue in the Journal of Bacteriology

Tue, 22 Aug 2017 17:55:00 +0000

Class III histidine kinases: a recently accessorized kinase domain in putative modulators of type IV pili based motility

Tue, 22 Aug 2017 17:53:23 +0000

Classic Spotlights: Selected highlights from the first 100 years of the Journal of Bacteriology

Tue, 13 Jun 2017 20:35:08 +0000

By staying together, two genes keep the motor running

Tue, 07 Feb 2017 21:38:10 +0000

Aquerium: a web application for comparative exploration of domain-based protein occurrences on the taxonomically clustered genome tree

Thu, 02 Feb 2017 21:40:38 +0000

Classic spotlight: Genetics of Escherichia coli chemotaxis

Sat, 22 Oct 2016 02:33:11 +0000

A direct-sensing galactose chemoreceptor recently evolved in invasive strains of Campylobacter jejuni

Fri, 21 Oct 2016 02:34:43 +0000

Classic spotlight: 16S rRNA redefines microbiology

Fri, 23 Sep 2016 02:37:07 +0000

The conserved TPR-containing C-terminal domain of Pseudomonas aeruginosa FimV is required for its cAMP-dependent and independent functions

Fri, 29 Jul 2016 02:42:38 +0000

Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes

Thu, 07 Apr 2016 02:40:42 +0000

Establishing precise evolutionary history of a gene improves predicting disease causing missense mutations

Fri, 19 Feb 2016 03:38:30 +0000

Evolutionary genomics suggests that CheV is an additional adaptor for accommodating specific chemoreceptors within the chemotaxis signaling complex

Fri, 05 Feb 2016 03:44:34 +0000

Joint mouse-human phenome-wide association to test gene function and disease risk

Wed, 03 Feb 2016 03:45:43 +0000

Databases for microbiologists

Tue, 07 Jul 2015 02:51:30 +0000

CDvist: a webserver for identification and visualization of conserved domains in protein sequences

Fri, 19 Dec 2014 03:47:37 +0000

Sisters Unbound is required for meiotic centromeric cohesion in Drosophila melanogaster

Sat, 06 Sep 2014 03:06:40 +0000

A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors

Sat, 14 Dec 2013 04:07:58 +0000

Conformational coupling between receptor and kinase binding sites through a conserved salt bridge in a signaling complex scaffold protein

Fri, 15 Nov 2013 04:11:39 +0000

SeqDepot: a streamlined database of protein sequences and precomputed features

Thu, 14 Nov 2013 04:05:16 +0000

Homology modeling of the CheW coupling protein of the chemotaxis signaling complex

Thu, 08 Aug 2013 03:15:14 +0000

Chemoreceptor gene loss and acquisition via horizontal gene transfer in Escherichia coli

Fri, 26 Jul 2013 03:10:34 +0000

Analysis of activator and repressor functions reveals the requirements for transcriptional control by LuxR, the master regulator of quorum sensing in Vibrio harveyi

Wed, 10 Jul 2013 03:09:22 +0000

The 3.2 A resolution structure of a Receptor:CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays

Tue, 14 May 2013 03:12:56 +0000

Dynamics of domain coverage of the protein sequence universe

Sat, 17 Nov 2012 04:16:33 +0000

Sequence, structure and evolution of cellulases in the glycosyl hydrolase family 48

Fri, 16 Nov 2012 04:18:09 +0000

Azospirillum genomes reveal transition of bacteria from aquatic to terrestrial environments

Fri, 23 Dec 2011 04:20:34 +0000

Cellulases: ambiguous non-homologous enzymes in a genomic perspective

Wed, 12 Oct 2011 03:22:03 +0000

Origins and diversification of a complex signal transduction system in prokaryotes

Wed, 30 Jun 2010 03:26:01 +0000

Evolution and phyletic distribution of two component signal transduction systems

Sun, 11 Apr 2010 03:23:45 +0000

A PAS-domain containing chemoreceptor couples dynamic changes in metabolism with chemotaxis

Wed, 03 Feb 2010 04:28:28 +0000

The MiST2 database: a comprehensive genomics resource on microbial signal transduction

Sun, 08 Nov 2009 04:32:46 +0000

Universal architecture of bacterial chemoreceptor arrays

Wed, 07 Oct 2009 03:34:24 +0000

HSP-HMMER: a tool for protein domain identification on a large scale

Thu, 11 Jun 2009 03:39:26 +0000

The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota

Fri, 03 Apr 2009 03:35:40 +0000

Conserved residues in the HAMP domain define a new family of proposed bipartite energy taxis receptors

Fri, 02 Jan 2009 04:40:34 +0000

It is computation time for bacteriology!

Fri, 02 Jan 2009 04:37:19 +0000

Towards environmental systems biology of Shewanella

Tue, 08 Jul 2008 03:42:42 +0000

CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis

Sun, 08 Jun 2008 01:25:38 +0000

Complete genome sequence of the complex carbohydrate-degrading marine bacterium Saccharophagus degradans strain 2-40 T

Sat, 31 May 2008 03:44:33 +0000

Genome sequence of the Crenarchaeal hyperthermophile Thermofilum pendens reveals an unprecedented loss of biosynthetic pathways in a free-living organism

Wed, 16 Apr 2008 03:45:52 +0000

Bacterial sensing and motility: sure bets

Sun, 16 Mar 2008 03:48:07 +0000

FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes

Thu, 13 Sep 2007 03:51:22 +0000

Comparative genomic and protein sequence analyses of a complex system controlling bacterial chemotaxis

Tue, 03 Jul 2007 03:54:03 +0000

Evolutionary genomics reveals conserved structural determinants of signaling and adaptation in microbial chemoreceptors

Wed, 21 Feb 2007 04:49:30 +0000

MiST: a Microbial Signal Transduction database

Wed, 29 Nov 2006 04:52:59 +0000

Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73 M bp genome shaped for versatility

Fri, 11 Aug 2006 03:55:52 +0000

Chemotaxis in soil diazotrophs: survival and adaptive response

Thu, 15 Jun 2006 03:57:14 +0000

Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901

Fri, 25 Nov 2005 05:01:37 +0000

Four-helical bundle: a ubiquitous sensory module in prokaryotic signal transduction

Wed, 09 Nov 2005 05:00:23 +0000

One-component regulators dominate signal transduction in prokaryotes

Wed, 16 Feb 2005 04:58:19 +0000

Ecological role of energy taxis

Mon, 02 Feb 2004 05:03:03 +0000

Digging with experimental pick and computational shovel: a new addition to the histidine kinase superfamily

Thu, 15 Jan 2004 05:04:16 +0000

Model of bacterial band formation in aerotaxis

Wed, 03 Dec 2003 05:05:39 +0000

Aer and Tsr guide Escherichia coli in spatial gradients of oxidizable substrates

Mon, 01 Sep 2003 04:07:43 +0000

Molecular evolution of sensory domains in cyanobacterial chemoreceptors

Mon, 05 May 2003 04:09:08 +0000

The NIT domain: a predicted nitrate responsive module in bacterial sensory receptors

Tue, 04 Mar 2003 22:36:01 +0000

Different evolutionary constraints on CheW and CheY proteins revealed by heterologous expression studies and protein sequence analysis

Thu, 16 Jan 2003 02:06:44 +0000

Common sensory domains in transmembrane receptors for diverse signal transduction pathways in Bacteria and Archaea

Thu, 02 Jan 2003 02:07:59 +0000

Dual recognition of the bacterial chemoreceptor by chemotaxis-specific domains of the CheR methyltransferase

Sat, 02 Nov 2002 02:18:01 +0000

Predicted structure and phyletic distribution of the RNA binding protein Hfq

Mon, 02 Sep 2002 01:19:34 +0000

Positioning cloning of the murine flavivirus resistance gene

Wed, 10 Jul 2002 01:11:00 +0000

Bacillus subtilis and Its Closest Relatives: from Genes to Cells

Sun, 02 Jun 2002 01:15:43 +0000

A major chemotaxis gene cluster in Azospirillum brasilense and relationships between chemotaxis operons in α-proteobacteria

Thu, 07 Feb 2002 02:14:05 +0000

ANTAR: an RNA-binding domain in transcription antitermination regulatory proteins

Wed, 02 Jan 2002 02:00:00 +0000

Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences

Wed, 14 Nov 2001 02:22:59 +0000

CHASE: an extracellular sensing domain common to transmembrane receptors from prokaryotes, lower eukaryotes and plants

Tue, 02 Oct 2001 01:27:13 +0000

More than one way to sense chemicals

Thu, 16 Aug 2001 01:24:26 +0000

The superfamily of chemotaxis transducers: from physiology to genomics and back

Thu, 12 Jul 2001 14:55:00 +0000

Energy taxis is the dominant behavior in Azospirillum brasilense

Thu, 02 Nov 2000 02:28:23 +0000

A novel phototaxis receptor hidden in the cyanobacterial genome

Tue, 03 Oct 2000 01:29:27 +0000

Laccases are widespread in bacteria

Wed, 02 Feb 2000 02:30:36 +0000

Loss of cytochrome c oxidase activity and acquisition of resistance to quinone analogs in a laccase-positive variant of Azospirillum lipoferum

Fri, 19 Nov 1999 03:08:39 +0000

PAS domains: internal sensors of oxygen, redox potential, and light

Thu, 18 Feb 1999 03:00:41 +0000

PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox

Fri, 05 Sep 1997 01:55:44 +0000

Behavioral responses of Escherichia coli to changes in redox potential

Wed, 18 Sep 1996 01:48:55 +0000

Oxygen taxis and proton motive force in Azospirillum brasilense

Fri, 13 Sep 1996 01:40:03 +0000

Motility, chemokinesis, and methylation-independent chemotaxis in Azospirillum brasilense

Thu, 18 Mar 1993 01:31:34 +0000

The role of taxis in the ecology of Azospirillum

Mon, 03 Feb 1992 02:24:48 +0000

Behaviour of Azospirillum brasilense in a spatial gradient of oxygen and in a ‘redox’ gradient of an artificial electron acceptor

Mon, 02 Dec 1991 01:27:16 +0000

A rapid method for the measurement of bacterial chemotaxis

Thu, 02 May 1991 02:15:56 +0000